Mr. Veinz® is formulated to be the most cutting edge, stimulant-free, pump, and nootropic centric pre-workout on the market. Starting with the pumps, rather than using borrowed science like all the other ‘pump’ pre-workouts out there, Mr. Veinz® utilizes a multi-pathway approach for maximum vasodilation. Loaded with ingredients to address blood vessel relaxation, increase blood flow, enhance bioavailable endogenous nitric oxide production, and replenishment of vital minerals in the body to maximize pumps and performance. 

Rounding out Mr. Veinz® Stim-Free is a high potency, stimulant-free nootropic matrix. While pre-workout formulas have traditionally relied on stimulants for enhancing focus and training intensity, the route taken with Mr. Veinz® Stim-Free is utilizing novel, scientifically-backed nootropics. 

Massive pumps, enhanced nutrient delivery, and razor-sharp focus. Simply put, Mr. Veinz®  is stimulant-free pre-workouts, redefined. 

Begin by taking 1 small scoop (6.4) with 8-10 oz of cold water and consume 20-30 minutes prior to training. For those looking to maximize muscle pumps, vasodilation, and enhanced cognition state, users may use the 1 big scoop (12.8g). 

ADVANCED PUMP MATRIX

Nitrosigine®

A novel binding of arginine, inositol, and potassium silicate that combines to harness the coronary function-improving effects of both arginine and silicate in an inositol-stabilized form that delivers improved bioavailability of both the silicate and the arginine compared to traditional L-arginine alone

Research suggests that 1.5g of Nitrosigine® performs just as well, if not better than 8g of Citrulline Malate1

Works up to 500% more effectively than traditional Arginine HCL2

Significantly improves blood flow for muscle pumps via blood vessel relaxation3

Shown to improve the ability to perform complex cognitive tests requiring mental flexibility, processing speed, and executive functioning4

Promotes sustained muscle pumps and enhanced nutrient delivery5

Betaine Anhydrous 

Betaine, also known as trimethylglycine, is a compound found in plants like beets and spinach. Betaine is a natural osmolyte found in the cell that protects against dehydration by increasing cellular water retention through osmosis.

Previous research shows that supplementation with betaine improves muscle endurance, increases muscle mass, increases strength, and can reduce body fat. The increases in muscle strength are hypothesized to occur to an increase in muscle creatine concentrations.

The increases in muscle strength occur fairly rapidly as one study found that two weeks of betaine ingestion can significantly improve muscle endurance in a lower body workout by increasing the number of repetitions performed in the squat exercise, as well as improve the quality of the workout by enhancing the number of repetitions performed at 90% of the subjects maximal mean and peak power outputs. These improvements appear to occur within one week of supplementation.

Glycerpump™

GlycerPump ™ is a new and completely stable form of glycerol powder with a yield of 65% glycerol content. Glycerpump™ supports improved hydration and nutrient absorption due to its ability to enhance the cell’s ability to absorb water.

Visualize Glycerpump™ transforming your cells into ultra-absorbent sponges and encouraging them to soak up extra water and nutrients and thereby improving endurance, performance, cell volumization, muscle fullness, vascularity, and pumps! In simple terms, Glycerpump™ sends extra fluid into the muscles resulting in improved hydration, endurance, performance, and Massive Pumps!

Taurine

Considered a conditionally essential amino acid; Not used for protein synthesis but more so components of nervous system9

Vial for the function of muscle tissues; stabilizes cell membranes and aids in the transport of electrolytes (potassium, calcium, magnesium, and sodium)10

STIM-FREE COGNITIVE ELEVATION & FOCUS MATRIX

Choline Bitartrate

Choline Bitartrate is known as a Choline donor that helps enhance cognitive function through the increase of choline into the body. 

These increased levels of choline then trigger the body to increase the production of Acetylcholine. Acetylcholine is a neurotransmitter that is used in many processes in the body and increasing Acetylcholine production is the key to it’s benefits.

Choline Bitartrate has been associated with mental stimulation, cognitive boost, and improved memory. It also helps with cognitive endurance. 

L-Tyrosine

Naturally occurring amino acid found in the diet that is metabolized to produce catecholamines such as dopamine and adrenaline11

It seems to provide a 'safety buffer' of building blocks that can prolong the anti-stress effect of catecholamines by delaying depletion12

Shown to help decrease serotonin to dopamine ratio during exercise, decreasing the perception of fatigue13

Lion’s Mane (Hericium Erinaceus)

Yamabushitakek, more commonly known as Lion’s Mane is a mushroom that grows on old or dead broadleaf trees and is found in Japan and China.

Ultra-versatile, showing promise for an antibiotic, anticarcinogenic, antidiabetic, antifatigue, antihypertensive, antihyperlipidemic, antisenescence, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties and improvement of anxiety, cognitive function, and depression22

Shown to significantly reduce the rate of cognitive decline and neuro degeneration23

Enhances neuronal communication and nerve regeneration via improved myelination24

Potentially an effective anti-depressant through the modulation of monoamine neurotransmitters and proinflammatory cytokines as well as the regulation of brain-derived neurotrophic factor (BDNF) pathways25

REFERENCES

(1)        Rogers, J. Comparing the Acute Effects of Citrulline Malate and Nitrosigine Supplementation in Young Adults, 2019.

(2)        Proctor, S. A Novel Complex of Arginine-Silicate Improves Micro- and Macrovascular Function and Inhibits Glomerular Sclerosis in Insulin-Resistant JCR:LA-Cp Rats. Diabetologia 2005, 48 (9), 1925–1932. https://doi.org/10.1007/s00125-005-1862-8.

(3)        Rood-Ojalvo, S. The Benefits of Inositol-Stabilized Arginine Silicate as a Workout Ingredient. J. Int. Soc. Sports Nutr. 2015, 12 (Suppl 1), P14. https://doi.org/10.1186/1550-2783-12-S1-P14.

(4)        Kalman, D. Randomized Prospective Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized Arginine Silicate in Healthy Physically Active Adults. Nutrients 2016, 8 (11), 736. https://doi.org/10.3390/nu8110736.

(5)        Komorowski, J. A Pharmacokinetic Evaluation of the Duration of Effect of Inositol-Stabilized Arginine Silicate and Arginine Hydrochloride in Healthy Adult Males. Nutrition 2016, 30 (1).

(6)        Frestedt, J. A Natural Seaweed Derived Mineral Supplement (Aquamin F) for Knee Osteoarthritis: A Randomised, Placebo-Controlled Pilot Study. Nutr. J. 2009, 8 (7). https://doi.org/10.1186/1475-2891-8-7.

(7)        Ryan, S. Evidence That the Marine-Derived Multi-Mineral Aquamin Has Anti-Inflammatory Effects on Cortical Glial-Enriched Cultures. Phytother. Res. 2011, 25 (5), 765–767. https://doi.org/10.1002/ptr.3309.

(8)        Fekete, A. Casein-Derived Lactotripeptides Reduce Systolic and Diastolic Blood Pressure in a Meta-Analysis of Randomised Clinical Trials. Nutrients 2015, 7 (1), 659–681. https://doi.org/10.3390/nu7010659.

(9)        Wu, J.-Y. Role of Taurine in the Central Nervous System. J. Biomed. Sci. 2010, 17 (Suppl 1), S1. https://doi.org/10.1186/1423-0127-17-S1-S1.

(10)      Schaffer, S. Physiological Roles of Taurine in Heart and Muscle. J. Biomed. Sci. 2010, 17 (Suppl 1). https://doi.org/10.1186/1423-0127-17-S1-S2.

(11)      Fernstrom, J. Tyrosine, Phenylalanine, and Catecholamine Synthesis and Function in the Brain. J. Nutr. 2007, 137 (6), 1539S-1547S. https://doi.org/10.1093/jn/137.6.1539S.

(12)      Agharanya, J. Changes in Catecholamine Excretion after Short-Term Tyrosine Ingestion in Normally Fed Human Subjects. Am. J. Clin. Nutr. 1981, 34 (1), 82–87. https://doi.org/10.1093/ajcn/34.1.82.

(13)      Cordeiro, L. Physical Exercise-Induced Fatigue: The Role of Serotonergic and Dopaminergic Systems. Braz. J. Med. Biol. Res. 2017, 50 (12). https://doi.org/10.1590/1414-431X20176432.

(14)      Hausenblaus, H. Efficacy of Ashwagandha (Withania Somnifera) [NooGandha®] Supplementation on Adult’s Cortisol, Cognition, and Psychological Outcomes: A Randomized Double-Blind Placebo-Controlled Trial. Jacksonville University.

(15)      Auddy, B. A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study. J. Am. Nutraceutical Assoc. 2008, 11 (1).

(16)      Chandrasekhar. A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. Indian J. Psychol. Med. 2012, 34 (3), 255–262. https://doi.org/10.4103/0253-7176.106022.

(17)      Chudiwal, A. Alpinia Galanga Willd.- An Overview of Phyto-Pharmacological Properties. J. Nat. Prod. Resour. 2010, 1 (2), 143–149.

(18)      Srivastava, S. Effect of Alpinia Galanga on Mental Alertness and Sustained Attention With or Without Caffeine: A Randomized Placebo-Controlled Study. J. Am. Coll. Nutr. 36 (8), 631–639. https://doi.org/10.1080/07315724.2017.1342576.

(19)      Hanish Singh, J. Neurotransmitter Metabolic Enzymes and Antioxidant Status on Alzheimer’s Disease Induced Mice Treated with Alpinia Galanga (L.) Willd. J. Phytother. Res. 2011, 25 (7), 1061–1067. https://doi.org/10.1002/ptr.3364.

(20)      Mundugaru, R. Neuroprotective Functions of Alpinia Galanga in Forebrain Ischemia Induced Neuronal Damage and Oxidative Insults in Rat Hippocampus. Indian J. Pharm. Educ. Res. 2018, 52 (4). https://doi.org/10.5530/ijper.52.4s.79.

(21)      Kaushik, P. Protective Effect of Alpinia Galanga in STZ Induced Diabetic Nephropathy. Pak. J. Biol. Sci. 2013, 16 (16), 804–811. https://doi.org/10.3923/pjbs.2013.804.811.

(22)      Friedman, M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium Erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. J. Agric. Food Chem. 2015, 63 (32), 7108–7123. https://doi.org/10.1021/acs.jafc.5b02914.

(23)      Mori, K. Improving Effects of the Mushroom Yamabushitake (Hericium Erinaceus) on Mild Cognitive Impairment: A Double-Blind Placebo-Controlled Clinical Trial. J. Phytother. Res. 2009, 23 (3), 367–372. https://doi.org/10.1002/ptr.2634.

(24)      Kolotushkina, E. The Influence of Hericium Erinaceus Extracts on Myelination Process in Vitro. Fiziol Zh 2003, 49 (1), 38–45.

(25)      Chiu, C. Erinacine A-Enriched Hericium Erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. Int. J. Mol. Sci. 2018, 19 (2). https://doi.org/10.3390/ijms19020341.